Project description

Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long-term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immune and neurological effects. Risk assessment is performed with an additive model for mixture toxicity. Based on this the Toxic Equivalency (TEQ) concept was developed as a biomarker for exposure and risk.

TEQs are the sum of congener-specific toxic equivalency factors (TEFs) multiplied by the concentration in a matrix, e.g., blood. TEF values are a composite quantitative value from a range of biomarkers that are congener- and endpoint-specific. Present human TEQs have been derived from oral administration experiments providing ‘intake’ TEFs. Regulatory authorities frequently use ‘intake’ TEQs for blood and tissues considering it a biomarker for exposure or effect. Experimental evidence shows that using ‘uptake’ TEQs as ‘systemic’ biomarkers may lead to misinterpretation of risks. Therefore, development and validation of ‘systemic’ TEFs and TEQs as biomarkers is necessary.

Major objectives of SYSTEQ are: i) establish ‘systemic’ TEFs and TEQs; ii) identify novel quantifiable biomarkers with newest molecular methods, e.g., genetic fingerprinting profiles; iii) extra focus on effects in peripheral lymphocytes as biomarkers; iv) identify differences between humans and experimental species. The ‘systemic’ TEFs and TEQs from SYSTEQ will be used in conjunction with results of the completed EU-funded PCBRISK project, in which two populations from Slovakia with very different exposure were studied. Individual blood levels and different biomarkers are already available. Results of SYSTEQ are also going to be used to establish international consensus values of ‘systemic’ TEFs at WHO level, facilitating the global use of ‘systemic’ TEQs as biomarkers of effect and exposure.

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SYSTEQ is funded under the FP7-ENVIRONMENT programme of the European Commission.